Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus


South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n = 142) versus non-T2DM (n = 76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = -0.419, P <0.01; r = -0.443, P <0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.

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Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences
Additional Information: Copyright © 2012 Alison L. Harte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Medicine(all),Endocrinology, Diabetes and Metabolism,Music
Publication ISSN: 1687-5303
Last Modified: 29 Feb 2024 08:10
Date Deposited: 02 Aug 2012 09:51
Full Text Link: http://www.hind ... dr/2012/895185/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2012
Authors: Harte, Alison L.
da Silva, Nancy F.
Miller, Michelle A.
Cappuccio, Francesco P.
Kelly, M. Ann
O'Hare, Joseph P.
Barnett, Anthony H.
Al-Daghri, Nasser M
Al-Attas, Omar
Alokail, Majed
Sabico, Shaun
Tripathi, Gyanendra
Bellary, Srikanth (ORCID Profile 0000-0002-5924-5278)
Kumar, Sudhesh
McTernan, Philip G.



Version: Published Version

License: Creative Commons Attribution

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