Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy):possible pathomechanism of human cervical compressive myelopathy


Cervical compressive myelopathy is the most serious complication of cervical spondylosis or ossification of the posterior longitudinal ligament (OPLL) and the most frequent cause of spinal cord dysfunction. There is little information on the exact pathophysiological mechanism responsible for the progressive loss of neural tissue in the spinal cord of such patients. In this study, we used the spinal hyperostotic mouse (twy/twy) as a suitable model of human spondylosis, and OPLL to investigate the cellular and molecular changes in the spinal cord. Mutant twy/twy mouse developed ossification of the ligamentum flavum at C2-C3 and exhibited progressive paralysis.

Publication DOI: https://doi.org/10.1007/s00586-011-2025-x
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: Creative Commons Attribution. © The Author(s) 2011. The original publication is available at www.springerlink.com
Uncontrolled Keywords: Surgery,Orthopedics and Sports Medicine
Publication ISSN: 1432-0932
Last Modified: 03 Jul 2024 07:03
Date Deposited: 04 Jul 2012 11:22
Full Text Link: http://www.spri ... 22ggq103411194/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2012-03
Authors: Uchida, Kenzo
Nakajima, Hideaki
Watanabe, Shuji
Yayama, Takafumi
Guerrero, Alexander R.
Inukai, Tomoo
Hirai, Takayuki
Sugita, Daisuke
Johnson, William E
Baba, Hisatoshi



Version: Published Version

License: Creative Commons Attribution

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