The haematopoietic stem cell niche:new insights into the mechanisms regulating haematopoietic stem cell behaviour


The concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the 1970s, as a region within the bone marrow containing functional cell types that can maintain HSC potency throughout life. Since then, ongoing research has identified numerous cell types and a plethora of signals that not only maintain HSCs, but also dictate their behaviour with respect to homeostatic requirements and exogenous stresses. It has been proposed that there are endosteal and vascular niches within the bone marrow, which are thought to regulate different HSC populations. However, recent data depicts a more complicated picture, with functional crosstalk between cells in these two regions. In this review, recent research into the endosteal/vascular cell types and signals regulating HSC behaviour are considered, together with the possibility of a single subcompartmentalised niche.

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Divisions: College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
College of Health & Life Sciences > School of Biosciences
Additional Information: Copyright © 2011 Andrew J. Lilly et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Cell Biology,Molecular Biology
Publication ISSN: 1687-9678
Last Modified: 19 Feb 2024 08:07
Date Deposited: 29 May 2012 12:17
Full Text Link: http://www.hind ... ci/2011/274564/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2011
Authors: Lilly, Andrew J.
Johnson, William E.
Bunce, Christopher M.



Version: Published Version

License: Creative Commons Attribution

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