Functional proteomics to dissect tyrosine kinase signalling pathways in cancer


Advances in the generation and interpretation of proteomics data have spurred a transition from focusing on protein identification to functional analysis. Here we review recent proteomics results that have elucidated new aspects of the roles and regulation of signal transduction pathways in cancer using the epidermal growth factor receptor (EGFR), ERK and breakpoint cluster region (BCR)-ABL1 networks as examples. The emerging theme is to understand cancer signalling as networks of multiprotein machines which process information in a highly dynamic environment that is shaped by changing protein interactions and post-translational modifications (PTMs). Cancerous genetic mutations derange these protein networks in complex ways that are tractable by proteomics.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: Copyright © 2010, Springer Nature
Uncontrolled Keywords: animals,humans,neoplasms,protein binding,post-translational protein processing,protein-tyrosine kinases,proteomics,signal transduction,Cancer Research,Oncology
Publication ISSN: 1474-1768
Last Modified: 22 May 2024 07:09
Date Deposited: 27 Apr 2012 12:20
Full Text Link: https://researc ... ndle/10197/5073
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2010-09
Authors: Kolch, Walter
Pitt, Andrew (ORCID Profile 0000-0003-3619-6503)



Version: Accepted Version

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