Walshe, Valerie A., Hattotuwagama, Channa K., Doytchinova, Irini A., Wong, MaiLee, Macdonald, Isabel K., Mulder, Arend, Claas, Frans H.J., Pellegrino, Pierre, Turner, Jo, Williams, Ian, Turnbull, Emma L., Borrow, Persephone and Flower, Darren R (2009). Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102:a bioinformatic approach to the prediction of new epitopes. PLoS ONE, 4 (11),
Abstract
Predictive models of peptide-Major Histocompatibility Complex (MHC) binding affinity are important components of modern computational immunovaccinology. Here, we describe the development and deployment of a reliable peptide-binding prediction method for a previously poorly-characterized human MHC class I allele, HLA-Cw*0102.
| Publication DOI: | https://doi.org/10.1371/journal.pone.0008095 |
|---|---|
| Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences College of Health & Life Sciences > Chronic and Communicable Conditions |
| Additional Information: | © 2009 Walshe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Uncontrolled Keywords: | alleles,amino acid motifs,computational biology,edetic acid,epitopes,HIV-1,HLA-C antigens,histocompatibility antigens class I,humans,mononuclear leukocytes,major histocompatibility complex,statistical models,peptides,protein binding,tertiary protein structure,General Agricultural and Biological Sciences,General Biochemistry,Genetics and Molecular Biology,General Medicine |
| Publication ISSN: | 1932-6203 |
| Last Modified: | 03 Dec 2024 08:05 |
| Date Deposited: | 22 Mar 2012 12:36 |
| Full Text Link: |
http://www.plos ... al.pone.0008095 |
| Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
| Published Date: | 2009 |
| Authors: |
Walshe, Valerie A.
Hattotuwagama, Channa K. Doytchinova, Irini A. Wong, MaiLee Macdonald, Isabel K. Mulder, Arend Claas, Frans H.J. Pellegrino, Pierre Turner, Jo Williams, Ian Turnbull, Emma L. Borrow, Persephone Flower, Darren R ( 
0000-0002-8542-7067)
|
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