Horspool, Keith R. (1988). Structure-Activity Studies on Antitumour Imidazotetrazionones. PHD thesis, Aston University.
Abstract
A review of the chemical and antitumour properties of imidazotetrazinones and in particular for that of mitozolomide, 8-carbamoyl-3-(2- chloroethyl)imidazo[5.1-d]-1.2.3.5-tetrazin-4(3H)-one (CMCIT) is presented. Previously proposed mechanisms of action for CMCIT are described, with special attention being given to its alkylating properties, conferred by the 3-chloroethyl substituent...
| Publication DOI: | https://doi.org/10.48780/publications.aston.ac.uk.00012550 |
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| Divisions: | College of Health & Life Sciences |
| Additional Information: | Copyright © Horspool, K. R., 1988. Horspool, K. R. asserts their moral right to be identified as the author of this thesis. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without appropriate permission or acknowledgement. If you have discovered material in Aston Publications Explorer which is unlawful e.g. breaches copyright, (either yours or that of a third party) or any other law, including but not limited to those relating to patent, trademark, confidentiality, data protection, obscenity, defamation, libel, then please read our Takedown Policy and contact the service immediately. |
| Institution: | Aston University |
| Uncontrolled Keywords: | Structure-activity,antitumour,imidazotetrazionones |
| Last Modified: | 01 Apr 2025 14:30 |
| Date Deposited: | 24 Jan 2011 11:45 |
| Completed Date: | 1988 |
| Authors: |
Horspool, Keith R.
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