Pearson, Paul G. (1985). The Metabolism and Hepatotoxicity of N-Methylformamide. PHD thesis, Aston University.
Abstract
Aspects of the metabolism and hepatotoxicity of the industrial solvent and investigational antitumour agent, N-methylformamide (NMF, OHCNHCH ) have been evaluated in mice. NMF was metabolised extensively in vivo, depleted hepatic glutathione (GSH) stores, and caused centrilobular necrosis in the liver. Pretreatment of mice with N-acetylcysteine prevented the hepatic GSH depletion and hepatotoxicity. Conversely depletion of hepatic GSH prior to NMF administration lowered the hepatotoxic dose threshold of NMF...
| Publication DOI: | https://doi.org/10.48780/publications.aston.ac.uk.00012500 |
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| Divisions: | College of Health & Life Sciences |
| Additional Information: | Copyright ©Pearson, P. G, 1985. Pearson, P. G asserts their moral right to be identified as the author of this thesis. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without appropriate permission or acknowledgement. If you have discovered material in Aston Publications Explorer which is unlawful e.g. breaches copyright, (either yours or that of a third party) or any other law, including but not limited to those relating to patent, trademark, confidentiality, data protection, obscenity, defamation, libel, then please read our Takedown Policy and contact the service immediately. |
| Institution: | Aston University |
| Uncontrolled Keywords: | metabolism,hepatotoxicity,N-Methylformamide |
| Last Modified: | 02 Apr 2025 08:26 |
| Date Deposited: | 24 Jan 2011 14:10 |
| Completed Date: | 1985 |
| Authors: |
Pearson, Paul G.
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