Role of the Klebsiella Aerogenes Envelope in Resistance to Antibiotics and Host Defences

Abstract

The nutritional requirements of Klebsiella aerogenes DL1i were quantitatively defined using a chemically defined medium (CDM). Antibiotic sensitivity patterns were determined using nutrient-depleted cultures. Iron-depleted (CDM-Fe) K. aerogenes DL1 was more sensitive to polymyxin than magnesium-depleted or log phase DL1. Loss by mutation of the K and O antigens failed to increase the sensitivity of K. aerogenes to a range of hydrophilic and hydrophobic antibiotics...

Publication DOI: https://doi.org/10.48780/publications.aston.ac.uk.00012479
Divisions: College of Health & Life Sciences
Additional Information: Copyright © Williams, P. , 1983. Williams, P. asserts their moral right to be identified as the author of this thesis. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without appropriate permission or acknowledgement. If you have discovered material in Aston Publications Explorer which is unlawful e.g. breaches copyright, (either yours or that of a third party) or any other law, including but not limited to those relating to patent, trademark, confidentiality, data protection, obscenity, defamation, libel, then please read our Takedown Policy and contact the service immediately.
Institution: Aston University
Uncontrolled Keywords: Klebsiella aerogenes envelope,resistance,antibiotics,host defences
Last Modified: 20 Mar 2025 14:54
Date Deposited: 24 Jan 2011 14:24
Completed Date: 1983
Authors: Williams, Paul

Export / Share Citation


Statistics

Additional statistics for this record