Whitby, Helen M. (1983). Studies on the Metabolism and Toxicity of N-Methyl Containing Compounds. PHD thesis, Aston University.
Abstract
The influence of several factors on the oxidative metabolism of hexamethylmelamine (HMM), procarbazine, caffeine, aminopyrine (AP), N-methylformamide (NMF), and N,N-dimethylformamide was investigated in vivo. Mice were administered 14C-methyl labelled compounds and the fate of the N-methyl moiety was monitored by 14CO2 exhaled with the breath. The 14CO2 exhalation profile for caffeine, but not HMM, was shown to be dependent on the dose. The influence on caffeine metabolism of inhibition or induction of cytochrome P450 dependent enzymes using SKF 525A or phenobarbitone, respectively, also depended on the dose of caffeine...
| Publication DOI: | https://doi.org/10.48780/publications.aston.ac.uk.00012460 |
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| Divisions: | College of Health & Life Sciences |
| Additional Information: | Copyright © Whitby, H. M, 1983. Whitby, H. M asserts their moral right to be identified as the author of this thesis. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without appropriate permission or acknowledgement. If you have discovered material in Aston Publications Explorer which is unlawful e.g. breaches copyright, (either yours or that of a third party) or any other law, including but not limited to those relating to patent, trademark, confidentiality, data protection, obscenity, defamation, libel, then please read our Takedown Policy and contact the service immediately. |
| Institution: | Aston University |
| Uncontrolled Keywords: | metabolism,toxicity,N-methyl |
| Last Modified: | 21 Mar 2025 14:50 |
| Date Deposited: | 24 Jan 2011 14:35 |
| Completed Date: | 1983 |
| Authors: |
Whitby, Helen M.
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