Guest, Anne E. (1984). Studies of Folate Catabolism in the Rat. PHD thesis, Aston University.
Abstract
The metabolism of a mixture of [2-14C] and [3',5',7,9-3H]-folic acid was studied in adult male and adult female rats. Both sexes were found to metabolise folic acid to various compounds. Intact folates and catabolites were excreted in the urine and folate polyglutamates were found in the tissues. The extent of tissue uptake and catabolism were found to vary between the male and female rat. Female rats treated with diethylstilboestrol and mazola corn oil showed marked changes in the metabolic handling of folic acid. Less radioactivity was excreted in the urine and catabolism was greatly reduced. There was also a major shift towards 10CHO-folate in the urinary metabolites...
| Publication DOI: | https://doi.org/10.48780/publications.aston.ac.uk.00011723 |
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| Divisions: | College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry |
| Additional Information: | Copyright © Anne E. Guest, 1984. Anne E. Guest asserts their moral right to be identified as the author of this thesis. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without appropriate permission or acknowledgement. If you have discovered material in Aston Publications Explorer which is unlawful e.g. breaches copyright, (either yours or that of a third party) or any other law, including but not limited to those relating to patent, trademark, confidentiality, data protection, obscenity, defamation, libel, then please read our Takedown Policy and contact the service immediately. |
| Institution: | Aston University |
| Uncontrolled Keywords: | Folate catabolism,rat |
| Last Modified: | 27 Mar 2025 09:28 |
| Date Deposited: | 12 Jan 2011 11:35 |
| Completed Date: | 1984-05 |
| Authors: |
Guest, Anne E.
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