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Article

Mackie, Duncan I., Al Mutairi, Fuad, Davis, Reema B., Kechele, Daniel O., Nielsen, Natalie R., Snyder, Joshua C., Caron, Marc G., Kliman, Harvey J., Berg, Jonathan S., Simms, John, Poyner, David R. and Caron, Kathleen M. (2018). hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. Journal of Experimental Medicine ,

Simms, John, Uddin, Romez, Sakmar, Thomas P., Gingell, Joseph J., Garelja, Michael L., Hay, Debbie L., Brimble, Margaret A., Harris, Paul W. R., Reynolds, Christopher Arthur and Poyner, David R. (2018). Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex. Biochemistry ,

Uddin, Romez, Simms, John and Poyner, David (2018). Functional characterisation of G protein-coupled receptors. Methods ,

Coudrat, Thomas, Simms, John, Christopoulos, Arthur, Wootten, Denise and Sexton, Patrick M. (2017). Improving virtual screening of G protein-coupled receptors via ligand-directed modeling. PLoS computational biology, 13 (11), e1005819.

Woolley, Michael J., Simms, John, Uddin, Sifat, Poyner, David R. and Conner, Alex C. (2017). Relative antagonism of mutants of the CGRP receptor extracellular loop 2 domain (ECL2) using a truncated competitive antagonist (CGRP8-37):evidence for the dual involvement of ECL2 in the two-domain binding model. Biochemistry, 56 (30), pp. 3877-3880.

Woolley, Michael J., Reynolds, Christopher A., Simms, John, Walker, Christopher S., Mobarec, Juan Carlos, Garelja, Michael L., Conner, Alex C., Poyner, David R. and Hay, Debbie L. (2017). Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochemical Pharmacology, in pre ,

Woolley, Michael J., Simms, John, Mobarec, Juan Carlos, Reynolds, Christopher A., Poyner, David R. and Conner, Alex C. (2017). Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach. Molecular and Cellular Endocrinology, in pre ,

Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism. Cell, 165 (7), pp. 1632-1643.

Gingell, Joseph J., Simms, John, Barwell, James, Poyner, David R., Watkins, Harriet A., Pioszak, Augen A., Sexton, Patrick M. and Hay, Debbie L. (2016). An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. Cell Discovery, 2 ,

Wootten, Denise, Reynolds, Christopher A., Koole, Cassandra, Smith, Kevin J., Mobarec, Juan C., Simms, John, Quon, Tezz, Coudrat, Thomas, Furness, Sebastian G.B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism:lessons from class B crystal structuress. Molecular Pharmacology, 89 (3), pp. 335-347.

Booe, Jason M., Walker, Christopher S., Barwell, James, Kuteyi, Gabriel, Simms, John, Jamaluddin, Muhammad A., Warner, Margaret L., Bill, Roslyn M., Harris, Paul W., Brimble, Margaret A., Poyner, David R., Hay, Debbie L. and Pioszak, Augen A. (2015). Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor. Molecular Cell, 58 (6), pp. 1040-1052.

Harris, Nicola J., Findlay, Heather E., Simms, John, Liu, Xia and Booth, Paula J. (2014). Relative domain folding and stability of a membrane transport protein. Journal of Molecular Biology, 426 (8), pp. 1812-1825.

Wheatley, M., Wootten, Denise, Conner, Matthew T., Simms, John, Kendrick, R., Logan, R.T., Poyner, David R. and Barwell, James (2012). Lifting the lid on GPCRs:the role of extracellular loops. British Journal of Pharmacology, 165 (6), pp. 1688-1703.

Koole, Cassandra, Wootten, Denise, Simms, John, Savage, Emilia E., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2012). Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. Journal of Biological Chemistry, 287 (6), pp. 3659-3673.

Koole, Cassandra, Wootten, Denise, Simms, John, Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2012). Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation. Journal of Biological Chemistry, 287 (6), pp. 3642-3658.

Koole, Cassandra, Wootten, Denise, Simms, John, Valant, Celine, Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2011). Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function:Allosteric rescue of loss of function mutation. Molecular Pharmacology, 80 (3), pp. 486-497.

Koole, Cassandra, Wootten, Denise, Simms, John, Valant, Celine, Sridhar, Rohan, Woodman, Owen L., Miller, Laurence J., Summers, Roger J., Christopoulos, Arthur and Sexton, Patrick M. (2010). Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner:Implications for drug screening. Molecular Pharmacology, 78 (3), pp. 456-465.

Harikumar, Kaleeckal G., Simms, John, Christopoulos, George, Sexton, Patrick M. and Miller, Laurence J. (2009). Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. Biochemistry, 48 (49), pp. 11773-11785.

Conner, Matthew, Hawtin, Stuart R., Simms, John, Wootten, Denise, Lawson, Zoe, Conner, Alex C., Parslow, Rosemary A. and Wheatley, Mark (2007). Systematic analysis of the entire second extracellular loop of the V 1a vasopressin receptor :Key residues, conserved throughout a G-protein-coupled receptor family, identified. Journal of Biological Chemistry, 282 (24), pp. 17405-17412.

Conner, Alex C., Simms, John, Howitt, Stephen G., Wheatley, Mark and Poyner, David R. (2006). The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression. Journal of Biological Chemistry, 281 (3), pp. 1644-1651.

This list was generated on Sat Sep 21 02:08:58 2019 BST.