Neurodevelopmental outcomes in paediatric immune-mediated and autoimmune epileptic encephalopathy

Abstract

Recognition of paediatric autoimmune/immune-mediated encephalitis and epileptic encephalopathy (e.g. NMDAR-Ab encephalitis) has rapidly increased over the last ten years. While we are succeeding in the diagnosis and identification and even early treatment of these encephalitidies, with studies describing >80% are making a “good” recovery, we are now recognising that a “good” medical outcome does not cover the cognitive, social and behavioural sequelae that can occur, particularly in paediatric patients. Basic measures of medical outcome, for example the modified Rankin Scale (MRS) or the Paediatric Cerebral Performance Category (PCPC), offer the advantage of being quick to use, but do not reveal the more complex difficulties that can impact the future of affected children. This article reviews the current literature on neurodevelopmental outcomes in children affected with autoimmune and immune-mediated encephalitis/epileptic encephalopathy and provides guidance on post-onset surveillance aimed at identifying those most likely to experience ongoing long-term difficulties.

Publication DOI: https://doi.org/10.1016/j.ejpn.2019.12.010
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Life & Health Sciences > Psychology
Additional Information: © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: European Research Council Consolidator Fellowship (ERC-CoG2015-PROBIt-682734). Epilepsy Research UK Postdoctoral Fellowship (F1601) and a Wellcome Trust Clinical Research Career Development Fellowship (216613/Z/19/Z).
Uncontrolled Keywords: ADEM,Autoimmune encephalitis,Cognition/behaviour,MOG antibodies,Neurodevelopmental outcomes,Paediatric NMDAR-Ab encephalitis,Pediatrics, Perinatology, and Child Health,Clinical Neurology
Full Text Link:
Related URLs: https://linking ... 090379819304301 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Online Date: 2019-12-20
Authors: Wright, Sukhvir K. ( 0000-0002-5464-3779)
Wood, Amanda G. ( 0000-0002-1537-6858)

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Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 20 December 2020.

License: Creative Commons Attribution Non-commercial No Derivatives


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