Blood pressure, aortic stiffness, hemodynamics and cognition in twin pairs discordant for type 2 diabetes

Karayiannis, C, Moran, C, Sharman, J E, Beare, R, Quinn, S J, Phan, T G, Wood, Amanda, Thrift, A G, Wang, W C and Srikanth, V (2019). Blood pressure, aortic stiffness, hemodynamics and cognition in twin pairs discordant for type 2 diabetes. Journal of Alzheimer's disease ,


Background: Type 2 diabetes (T2D) is associated with an increased risk of cognitive impairment and dementia with poorly understood underlying mechanisms. Objective: We examined the role of blood pressure (BP), aortic stiffness, and hemodynamics in this association. Methods: Cross-sectional sample of late middle-aged twins discordant for T2D from the Australian Twin Registry. Measurements included neuropsychological battery and brain MRI including Arterial Spin Labelling (ASL) to measure cerebral perfusion. Mobil-o-Graph devices were used to non-invasively obtain 24hr BP, aortic stiffness and hemodynamic measures. Using mixed modelling, we studied associations of T2D with cognition, MRI measures, BP, aortic stiffness and hemodynamics. Results: There were 23 twin pairs with mean age 63.7 (SD=6.1) years. T2D (β=-0.45, p<0.001) and age (β=-0.05, p=0.022) were independently associated with poorer attention but not with memory or perceptual speed. T2D was associated with reduced nocturnal central systolic BP dipping (β=-3.79, p=0.027), but not with BP, aortic stiffness, cerebral perfusion, or other hemodynamic measures. There was a statistically significant interaction between T2D and central systolic BP dipping in predicting attention scores (both p<0.05 for the interaction term) whereby there was a positive association between BP dipping and attention scores in those with T2D, but not in those without T2D. Conclusion: We found an association between T2D and reduced nocturnal central systolic dipping, but not with any other measures of BP, stiffness or hemodynamic measures. Further 3 study of the role of nocturnal central BP dipping in the association between T2D and cognitive impairment may help identify potential mechanisms.

Publication DOI:
Divisions: Life & Health Sciences > Psychology
Life & Health Sciences
Additional Information: Copyright ©2019 IOS Press. Journal of Alzheimer's Disease, vol. Pre-press, no. Pre-press, pp. 1-11, 2019
Uncontrolled Keywords: Dementia,diabetes mellitus,type 2,blood pressure,vascular stiffness,Hemodynamics,cognitive dysfunction,Cerebrovascular Circulation
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Related URLs: https://content ... sease/jad190319 (Publisher URL)
Accepted Date: 2019-07-16
Published Online Date: 2019-08-16
Authors: Karayiannis, C
Moran, C
Sharman, J E
Beare, R
Quinn, S J
Phan, T G
Wood, Amanda ( 0000-0002-1537-6858)
Thrift, A G
Wang, W C
Srikanth, V



Version: Accepted Version

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