Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort

Becker, Jessica, Czamara, Darina, Scerri, Tom S., Ramus, Franck, Csépe, Valéria, Talcott, Joel B., Stein, John, Morris, Andrew, Ludwig, Kerstin U., Hoffmann, Per, Honbolygó, Ferenc, Tóth, Dénes, Fauchereau, Fabien, Bogliotti, Caroline, Iannuzzi, Stéphanie, Chaix, Yves, Valdois, Sylviane, Billard, Catherine, George, Florence, Soares-Boucaud, Isabelle, Gérard, Christophe-Loïc, van der Mark, Sanne, Schulz, Enrico, Vaessen, Anniek, Maurer, Urs, Lohvansuu, Kaisa, Lyytinen, Heikki, Zucchelli, Marco, Brandeis, Daniel, Blomert, Leo, Leppänen, Paavo H.T., Bruder, Jennifer, Monaco, Anthony P., Müller-Myhsok, Bertram, Kere, Juha, Landerl, Karin, Nöthen, Markus M., Schulte-Körne, Gerd, Paracchini, Silvia, Peyrard-Janvid, Myriam and Schumacher, Johannes (2014). Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort. European Journal of Human Genetics, 22 (5), pp. 675-680.

Abstract

Dyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from understanding the molecular mechanisms leading to the disorder. Several candidate genes have been implicated in dyslexia, including DYX1C1, DCDC2, KIAA0319, and the MRPL19/C2ORF3 locus, each with reports of both positive and no replications. We generated a European cross-linguistic sample of school-age children-the NeuroDys cohort-that includes more than 900 individuals with dyslexia, sampled with homogenous inclusion criteria across eight European countries, and a comparable number of controls. Here, we describe association analysis of the dyslexia candidate genes/locus in the NeuroDys cohort. We performed both case-control and quantitative association analyses of single markers and haplotypes previously reported to be dyslexia-associated. Although we observed association signals in samples from single countries, we did not find any marker or haplotype that was significantly associated with either case-control status or quantitative measurements of word-reading or spelling in the meta-analysis of all eight countries combined. Like in other neurocognitive disorders, our findings underline the need for larger sample sizes to validate possibly weak genetic effects. © 2014 Macmillan Publishers Limited All rights reserved.

Publication DOI: https://doi.org/10.1038/ejhg.2013.199
Divisions: Life & Health Sciences > Psychology
Life & Health Sciences
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Additional Information: © 2013, Publisher / the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.nature.com / https://dx.doi.org/10.1038/ejhg.2013.199
Uncontrolled Keywords: association study,candidate genes,dyslexia,spelling,word-reading,Genetics(clinical),Genetics,Medicine(all)
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2014-05-01
Authors: Becker, Jessica
Czamara, Darina
Scerri, Tom S.
Ramus, Franck
Csépe, Valéria
Talcott, Joel B. ( 0000-0001-7958-8369)
Stein, John
Morris, Andrew
Ludwig, Kerstin U.
Hoffmann, Per
Honbolygó, Ferenc
Tóth, Dénes
Fauchereau, Fabien
Bogliotti, Caroline
Iannuzzi, Stéphanie
Chaix, Yves
Valdois, Sylviane
Billard, Catherine
George, Florence
Soares-Boucaud, Isabelle
Gérard, Christophe-Loïc
van der Mark, Sanne
Schulz, Enrico
Vaessen, Anniek
Maurer, Urs
Lohvansuu, Kaisa
Lyytinen, Heikki
Zucchelli, Marco
Brandeis, Daniel
Blomert, Leo
Leppänen, Paavo H.T.
Bruder, Jennifer
Monaco, Anthony P.
Müller-Myhsok, Bertram
Kere, Juha
Landerl, Karin
Nöthen, Markus M.
Schulte-Körne, Gerd
Paracchini, Silvia
Peyrard-Janvid, Myriam
Schumacher, Johannes

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