The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure

Scerri, Thomas S., Darki, Fahimeh, Newbury, Dianne F., Whitehouse, Andrew J.O., Peyrard-Janvid, Myriam, Matsson, Hans, Ang, Qi W., Pennell, Craig E., Ring, Susan, Stein, John, Morris, Andrew P., Monaco, Anthony P., Kere, Juha, Talcott, Joel, Klingberg, Torkel and Paracchini, Silvia (2012). The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure. PLoS ONE, 7 (11),

Abstract

Independent studies have shown that candidate genes for dyslexia and specific language impairment (SLI) impact upon reading/language-specific traits in the general population. To further explore the effect of disorder-associated genes on cognitive functions, we investigated whether they play a role in broader cognitive traits. We tested a panel of dyslexia and SLI genetic risk factors for association with two measures of general cognitive abilities, or IQ, (verbal and non-verbal) in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (N>5,000). Only the MRPL19/C2ORF3 locus showed statistically significant association (minimum P = 0.00009) which was further supported by independent replications following analysis in four other cohorts. In addition, a fifth independent sample showed association between the MRPL19/C2ORF3 locus and white matter structure in the posterior part of the corpus callosum and cingulum, connecting large parts of the cortex in the parietal, occipital and temporal lobes. These findings suggest that this locus, originally identified as being associated with dyslexia, is likely to harbour genetic variants associated with general cognitive abilities by influencing white matter structure in localised neuronal regions.

Publication DOI: https://doi.org/10.1371/journal.pone.0050321
Divisions: Life & Health Sciences > Psychology
Life & Health Sciences > Clinical and Systems Neuroscience
Life & Health Sciences > Aston Brain Centre
Life & Health Sciences > Vision, Hearing and Language
Additional Information: © 2012 Scerri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords: Agricultural and Biological Sciences(all),Biochemistry, Genetics and Molecular Biology(all),Medicine(all)
Full Text Link: http://www.plos ... al.pone.0050321
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2012-11-28
Authors: Scerri, Thomas S.
Darki, Fahimeh
Newbury, Dianne F.
Whitehouse, Andrew J.O.
Peyrard-Janvid, Myriam
Matsson, Hans
Ang, Qi W.
Pennell, Craig E.
Ring, Susan
Stein, John
Morris, Andrew P.
Monaco, Anthony P.
Kere, Juha
Talcott, Joel ( 0000-0001-7958-8369)
Klingberg, Torkel
Paracchini, Silvia

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