Cardiac resynchronization therapy using endocardial versus trans-coronary sinus, epicardial left ventricular pacing: the Epi-Endo study

Abstract

Aims: Some studies have suggested that cardiac resynchronization therapy (CRT) using endocardial left ventricular (LV) pacing (Endo-CRT) is superior to a conventional transvenous, epicardial CRT (Epi-CRT). To determine whether, in CRT recipients, endocardial LV pacing is haemodynamically superior to trans-coronary vein (trans-CV) LV epicardial pacing. Methods and results: At implantation patients (n=16; aged 68.9±8.32 years; 13 male) underwent Epi-CRT and Endo-CRT in basal, mid and apical myocardial segments, delivered using the trans-CS lead and an intra-cavitary, roving EP catheter to achieve juxtapositions of the epicardial and endocardial side of the LV free wall respectively. Myocardial scar was quantified using cardiovascular magnetic resonance. An acute haemodynamic response (AHR) was defined as a ≥10% increase in the maximal rate of rise of LV pressure (%LV dP/dtmax) in relation to RV pacing (DOO). When the 84 paired segments were taken together, the %ΔLV dP/dtmax was higher with Endo-CRT than with Epi-CRT (9.9±8,6% vs 7.9±8.3% respectively, p

Publication DOI: https://doi.org/10.1093/europace/euae102.458
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Aston Medical School
Funding Information: Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Funding support received from Medtronic
Additional Information: © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/)
Publication ISSN: 1532-2092
Last Modified: 30 Sep 2024 13:46
Date Deposited: 29 May 2024 11:12
PURE Output Type: Meeting abstract
Published Date: 2024-05-24
Published Online Date: 2024-05-24
Authors: Okafor, O
Zegard, A
Stegemann, B (ORCID Profile 0000-0003-2841-8022)
Kalla, M
Lencioni, M
De Bono, J
Marshall, H
Leyva, F

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