The effect of simulated cataract light scatter on retinal vessel oximetry


To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter. © 2013 Elsevier Ltd.

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Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Experimental eye research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Patel, SR, Hudson, C, Flanagan, JG & Heitmar, R, 'The effect of simulated cataract light scatter on retinal vessel oximetry' Experimental eye research, vol. 116 (2013) DOI
Uncontrolled Keywords: cataract models,extraneous factors,light scatter,retinal oximetry,retinal oxygenation,Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
Publication ISSN: 1096-0007
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2013-11
Published Online Date: 2013-09-19
Authors: Patel, Sunni R.
Hudson, Chris
Flanagan, John G.
Heitmar, Rebekka (ORCID Profile 0000-0002-7657-1788)



Version: Accepted Version

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