Deep brain stimulation for chronic pain investigated with magnetoencephalography


Deep brain stimulation has shown remarkable potential in alleviating otherwise treatment-resistant chronic pain, but little is currently known about the underlying neural mechanisms. Here for the first time, we used noninvasive neuroimaging by magnetoencephalography to map changes in neural activity induced by deep brain stimulation in a patient with severe phantom limb pain. When the stimulator was turned off, the patient reported significant increases in subjective pain. Corresponding significant changes in neural activity were found in a network including the mid-anterior orbitofrontal and subgenual cingulate cortices; these areas are known to be involved in pain relief. Hence, they could potentially serve as future surgical targets to relieve chronic pain. © 2007 Lippincott Williams & Wilkins, Inc.

Publication DOI:
Divisions: Life & Health Sciences > Psychology
Life & Health Sciences > Clinical and Systems Neuroscience
Life & Health Sciences > Aston Brain Centre
Life & Health Sciences
Life & Health Sciences > Centre for Vision and Hearing Research
Uncontrolled Keywords: chronic pain,deep brain stimulation,magnetoencephalography,orbitofrontal cortex,phantom limb,subgenual cingulate cortex,Neuroscience(all)
Full Text Link: http://www.phys ... /nr_8_3_223.pdf
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://journals ... 6&type=abstract (Publisher URL)
PURE Output Type: Article
Published Date: 2007-02-12
Authors: Kringelbach, Morten L.
Jenkinson, Ned
Green, Alexander L.
Owen, Sarah L. F.
Hansen, Peter C.
Cornelissen, Piers L.
Holliday, Ian E.
Stein, John
Aziz, Tipu Z.

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