Real-time detection of DNA interactions with long-period fiber-grating-based biosensor

Chen, Xianfeng F., Zhang, Lin, Zhou, Kaiming, Davies, Edward, Sugden, Kate, Bennion, Ian, Hughes, Marcus D. and Hine, Anna V. (2007). Real-time detection of DNA interactions with long-period fiber-grating-based biosensor. Optics letters, 32 (17), pp. 2541-2543.


Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability.

Additional Information: © 2007 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.
Uncontrolled Keywords: biophotonics, DNA hybridisation, biosensor
Published Date: 2007-08-20
Authors: Chen, Xianfeng F.
Zhang, Lin
Zhou, Kaiming
Davies, Edward
Sugden, Kate
Bennion, Ian
Hughes, Marcus D.
Hine, Anna V.


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