Metamaterial formalism approach for advancing the recognition of glioma areas in brain tissue biopsies

Abstract

Early detection of a tumor makes it more probable that the patient will, finally, beat cancer and recover. The main goal of broadly defined cancer diagnostics is to determine whether a patient has a tumor, where it is located, and its histological type and severity. The major characteristic of the cancer affected tissue is the presence of the glioma cells in the sample. The current approach in diagnosis focuses mainly on microbiological, immunological, and pathological aspects rather than on the “metamaterial geometry” of the diseases. The determination of the effective properties of the biological tissue samples and treating them as disordered metamaterial media has become possible with the development of effective medium approximation techniques. Their advantage lies in their capability to treat the biological tissue samples as metamaterial structures, possessing the well-studied properties. Here, we present, for the first time to our knowledge, the studies on metamaterial properties of biological tissues to identify healthy and cancerous areas in the brain tissue. The results show that the metamaterial properties strongly differ depending on the tissue type, if it is healthy or unhealthy. The obtained effective permittivity values were dependent on various factors, like the amount of different cell types in the sample and their distribution. Based on these findings, the identification of the cancer affected areas based on their effective medium properties was performed. These results prove the metamaterial model capability in recognition of the cancer affected areas. The presented approach can have a significant impact on the development of methodological approaches toward precise identification of pathological tissues and would allow for more effective detection of cancer-related changes.

Publication DOI: https://doi.org/10.1364/OME.393604
Divisions: Engineering & Applied Sciences > Aston Institute of Photonics Technology
Engineering & Applied Sciences
Additional Information: Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Funding: Engineering and Physical Sciences Research Council (EP/R024898/1); the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska Curie grant agreement (713694); Russian Science Foundation (18-15-00172).
Uncontrolled Keywords: Electronic, Optical and Magnetic Materials
Full Text Link:
Related URLs: https://www.osa ... I=ome-10-7-1607 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2020-06-16
Accepted Date: 2020-04-27
Authors: Gric, Tatjana
Sokolovski, Sergei (ORCID Profile 0000-0001-7445-7204)
Navolokin, Nikita
Semyachkina-Glushkovskaya, Oxana
Rafailov, Edik U. (ORCID Profile 0000-0002-4152-0120)

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