A Revised Understanding of Clostridioides difficile Spore Germination

Abstract

The dormant resistant spores of Clostridioides difficile are transformed into metabolically active cells through the process of germination. Spore germination in C. difficile is regulated by the detection of bile salt germinants and amino acid cogerminants by pseudoproteases CspC and CspA, respectively. The germinant signal is transduced to the serine protease CspB, which processes the cortex lytic enzyme SleC, leading to degradation of the spore cortex peptidoglycan and subsequent reactivation of the spore. Divergent C. difficile germination models have been proposed to explain interactions between key regulators and transduction of germinant and cogerminant signals. This review summarises advances in understanding C. difficile germination and outlines current models of germination regulation.

Publication DOI: https://doi.org/10.1016/j.tim.2020.03.004
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences
Additional Information: © 2020 The Authors. Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)
Uncontrolled Keywords: C. difficile,cogerminant,germinant,germination,inhibitor,Microbiology,Microbiology (medical),Infectious Diseases,Virology
Full Text Link:
Related URLs: https://www.cel ... 075-5#secst0005 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2020-09-01
Published Online Date: 2020-04-23
Accepted Date: 2020-04-01
Authors: Lawler, Amelia
Lambert, Peter ( 0000-0002-8243-2741)
Worthington, Tony ( 0000-0002-1906-3357)

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