Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions

Abstract

There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance. Our results obtained at optical coherence tomography (OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function of the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying increasing the permeability of the lymphatic endothelium that allows molecules transported by the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These findings open new strategies for the stimulation of MLVs functions and non-pharmacological therapy of brain diseases.

Publication DOI: https://doi.org/10.1364/BOE.383390
Divisions: Engineering & Applied Sciences > Aston Institute of Photonics Technology
Additional Information: © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Authors and readers may use, reuse, and build upon the article, or use it for text or data mining without asking prior permission from the publisher or the Author(s), as long as the purpose is non-commercial and appropriate attribution is maintained. Funding: Russian Science Foundation (17-15-01263, 18-15-00172, 19-15-00201).
Uncontrolled Keywords: Biotechnology,Atomic and Molecular Physics, and Optics
Full Text Link:
Related URLs: https://www.osa ... RI=boe-11-2-725 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2020-02-01
Published Online Date: 2020-01-10
Accepted Date: 2020-01-05
Authors: Semyachkina-glushkovskaya, Oxana
Abdurashitov, Arkady
Dubrovsky, Alexander
Klimova, Maria
Agranovich, Ilana
Terskov, Andrey
Shirokov, Alexander
Vinnik, Valeria
Kuznecova, Anna
Lezhnev, Nikita
Blokhina, Inna
Shnitenkova, Anastassia
Tuchin, Valery
Rafailov, Edik (ORCID Profile 0000-0002-4152-0120)
Kurths, Jurgen

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