Automation in cell and gene therapy manufacturing:from past to future

Abstract

As more and more cell and gene therapies are being developed and with the increasing number of regulatory approvals being obtained, there is an emerging and pressing need for industrial translation. Process efficiency, associated cost drivers and regulatory requirements are issues that need to be addressed before industrialisation of cell and gene therapies can be established. Automation has the potential to address these issues and pave the way towards commercialisation and mass production as it has been the case for ‘classical’ production industries. This review provides an insight into how automation can help address the manufacturing issues arising from the development of large-scale manufacturing processes for modern cell and gene therapy. The existing automated technologies with applicability in cell and gene therapy manufacturing are summarized and evaluated here.

Publication DOI: https://doi.org/10.1007/s10529-019-02732-z
Divisions: Life & Health Sciences
Life & Health Sciences > Biosciences
Additional Information: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords: Automation,Bioreactors,Cell therapy,Gene therapy,Manufacturing,Biotechnology,Bioengineering,Applied Microbiology and Biotechnology
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://link.sp ... 529-019-02732-z (Publisher URL)
PURE Output Type: Review article
Published Date: 2019-11-01
Published Online Date: 2019-09-20
Accepted Date: 2019-09-12
Authors: Moutsatsou, P.
Ochs, J.
Schmitt, R. H.
Hewitt, C. J. ( 0000-0001-6988-6071)
Hanga, M. P. ( 0000-0002-2427-4052)

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