Matrix-assisted diffusion-ordered NMR spectroscopy with an invisible matrix:a vanishing surfactant

Abstract

The addition of co-solutes to aid the separation of signals from molecules of similar size in DOSY experiments – matrix-assisted DOSY – is a potentially powerful technique for mixture analysis. The additional signals introduced by a co-solute can however greatly complicate analysis. By suitable choice of sample conditions, the NMR peaks of a surfactant matrix can be suppressed, allowing the clear resolution of molecular species according to chemistry and structure, without extraneous interference.