Measuring the flow properties of small powder samples using an avalanche tester

Abstract

The feasibility of using a small-scale avalanche tester to measure the flow properties of pharmaceutical lactose powders was examined. The modes of behaviour observed in larger systems were displayed and showed a clear distinction between angular, free-flowing particles and more spherical particles of similar flow characteristics. Angular Lactohale LH100 particles showed slumping behaviour at a rotational frequency of 0.33Hz which disappeared at higher frequencies. Spherical lactose powder with a similar flow function to LH100 only showed rolling behaviour under the same conditions, as did more cohesive powders LH200 and LH300. Further investigation of the LH100 data using Fast Fourier analysis showed that the slumping frequency was 1/10th of the rotational frequency.

Publication DOI: https://doi.org/10.1080/07373937.2015.1072093
Divisions: Engineering & Applied Sciences > Chemical Engineering & Applied Chemistry
Engineering & Applied Sciences > Aston Institute of Materials Research (AIMR)
Life & Health Sciences > Pharmacy
Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Applied Health Research Group
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Drying Technology on 27/7/15, available online: http://www.tandfonline.com/10.1080/07373937.2015.1072093
Uncontrolled Keywords: pharmaceuticals,powder technology,rotary drying,Chemical Engineering(all),Physical and Theoretical Chemistry
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015-07-27
Published Online Date: 2015-07-27
Accepted Date: 2015-07-01
Authors: Jaggi, V.
Leaper, M.C.
Ingham, A.J.

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