Apoptotic cell-derived extracellular vesicles: structure-function relationships.

Abstract

Apoptosis is an essential process for normal physiology and plays a key role in the resolution of inflammation. Clearance of apoptotic cells (ACs) involves complex signalling between phagocytic cells, ACs, and the extracellular vesicles (EVs) they produce. Here, we discuss apoptotic cell-derived extracellular vesicles (ACdEVs) and how their structure relates to their function in AC clearance and the control of inflammation, focussing on the ACdEV proteome. We review the current knowledge, ongoing work and future directions for research in this field.

Publication DOI: https://doi.org/10.1042/BST20180080
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Life & Health Sciences > Cell & Tissue Biomedical Research
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Cellular and Molecular Biomedicine
Additional Information: © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
Uncontrolled Keywords: extracellular vesicles,macrophages,phagocytosis,Biochemistry
Full Text Link:
Related URLs: http://www.bioc ... 0.full-text.pdf (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2019-04-30
Published Online Date: 2019-04-05
Accepted Date: 2019-04-01
Authors: Grant, Lois
Milic, Ivana ( 0000-0001-7531-7561)
Devitt, Andrew ( 0000-0002-4651-6761)

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