The antimicrobial efficacy of zinc doped phosphate-based glass for treating catheter associated urinary tract infections

Abstract

In this study, a series of phosphate-based glasses; (P2O5)50(Na2O)20(CaO)30-x (ZnO)x were prepared with increasing concentration of zinc oxide to determine the antimicrobial effect against clinically relevant microorganisms. The addition of 1 and 3 mol% zinc oxide decreased glass degradation however a higher dissolution rate was observed for 5 and 10 mol% ZnO. The antimicrobial results showed a concentration dependent effect on the viability of microorganisms. When in direct contact zinc doped glasses showed a complete kill, within 24 h, against Escherichia coli and a significant (p < 0.01) kill was observed against Staphylococcus aureus however the effect of dissolution products was not seen until 48 h. Furthermore, the cytotoxic studies showed no toxic effects on the viability of uroepithelial cells. This study has shown that zinc doped phosphate-based glasses can potentially be used to prevent/treat catheter associated urinary tract infections.

Publication DOI: https://doi.org/10.1016/j.msec.2019.109868
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences
Engineering & Applied Sciences > Electrical, Electronic & Power Engineering
Engineering & Applied Sciences > Aston Institute of Materials Research (AIMR)
Engineering & Applied Sciences
Additional Information: © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: Insight Health Ltd, UK and ARCHA (Aston Research Centre for Healthy Ageing).
Uncontrolled Keywords: Materials Science(all),Condensed Matter Physics,Mechanics of Materials,Mechanical Engineering
Full Text Link:
Related URLs: https://linking ... 928493118323075 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2019-10-01
Published Online Date: 2019-06-06
Accepted Date: 2019-06-05
Authors: Raja, Farah N.s.
Worthington, T. ( 0000-0002-1906-3357)
Isaacs, Mark A.
Rana, Karan S.
Martin, Richard A. ( 0000-0002-6013-2334)

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