Contributions to our understanding of T cell physiology through unveiling the T cell proteome


Since the sequencing of the human genome was completed, attention has turned to examining the functionality of the molecular machinery, in particular of protein expression. Differential proteome analysis by two-dimensional electrophoresis has been adopted to study changes in T cell proteomes during T cell activation, and this work is increasing our understanding of the complexity of signals elicited across multiple pathways. The purpose of this review is to summarize the available evidence in the application of proteomic techniques and methodologies to understand T cell receptor activation from lipid raft and cytoskeletal rearrangements, through to signalling cascades, transcription factor modulation and changes in protein expression patterns. These include post-translational modifications, which are not encoded by the genome. © 2007 British Society for Immunology.

Publication DOI:
Divisions: Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Uncontrolled Keywords: 2D-PAGE,proteomics,t cells,Immunology
Full Text Link: https://www.ncb ... les/PMC1942030/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://onlineli ... 3395.x/abstract (Publisher URL)
Published Date: 2007-07
Authors: Grant, Melissa M.
Scheel-Toellner, D.
Griffiths, Helen R. ( 0000-0002-2666-2147)

Export / Share Citation


Additional statistics for this record