Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c Nude mouse model involves activation of the cell antioxidant system

Dolgova, D., Abakumova, T., Gening, T., Poludnyakova, L., Zolotovskii, Igor, Stoliarov, Dmitrii, Fotiadi, Andrei A., Khokhlova, Anna, Rafailov, Edik U. and Sokolovski, Sergei (2019). Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c Nude mouse model involves activation of the cell antioxidant system. Biomedical Optics Express, 10 (8), pp. 4261-4275.

Abstract

Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm2. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.

Publication DOI: https://doi.org/10.1364/BOE.10.004261
Divisions: Engineering & Applied Sciences > Aston Institute of Photonics Technology
Engineering & Applied Sciences
Additional Information: © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement Funding: Ministry of Education and Science of the Russian Federation (Government Assignment #3.3889.2017(I.Z., D.S., A.F., A.Kh.)). Russian Science Foundation (RSF) (# 18-15-00172 (E.R.)). EU H2020 FET research and innovation program MESO-BRAIN (#713140 (E.R., S.S.)). Leverhulme Trust (#VP2-2016-042, Visiting Professorship, Aston University (A.F.)).
Uncontrolled Keywords: BALB/c Nude mice,photobiomodulation,low-level lasers, 1270 nm,cell proliferation,cell antioxidant system,Atomic and Molecular Physics, and Optics,Biotechnology
Full Text Link:
Related URLs: https://www.osa ... i=boe-10-8-4261 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2019-07-31
Accepted Date: 2019-05-13
Authors: Dolgova, D.
Abakumova, T.
Gening, T.
Poludnyakova, L.
Zolotovskii, Igor
Stoliarov, Dmitrii
Fotiadi, Andrei A.
Khokhlova, Anna
Rafailov, Edik U. ( 0000-0002-4152-0120)
Sokolovski, Sergei ( 0000-0001-7445-7204)

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