Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

Abstract

We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuron-specific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-L-lysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced light-matter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thickness-tunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cut-off value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

Publication DOI: https://doi.org/10.1016/j.bios.2019.04.044
Divisions: Engineering & Applied Sciences > Electrical, Electronic & Power Engineering
Engineering & Applied Sciences > Aston Institute of Photonics Technology
Additional Information: © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: projects of EU FP7 PIRSES-GA-2013-612267 (iPhoto-Bio) and the Sêr Cymru NRN Fund (NRN097), and the National Natural Science Foundation of China (No.61571429 and 61801464).
Uncontrolled Keywords: Black phosphorus,Cancer biomarker,Fiber grating,Label-free,Neuron-specific enolase,Optical biosensor,Biotechnology,Biophysics,Biomedical Engineering,Electrochemistry
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Related URLs: https://linking ... 956566319303343 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2019-07-15
Published Online Date: 2019-04-25
Accepted Date: 2019-04-21
Authors: Zhou, Lin
Liu, Chen
Sun, Zhengbo
Mao, Hongju
Zhang, Lin ( 0000-0002-1691-5577)
Yu, Xuefeng
Zhao, Jianlong
Chen, Xianfeng

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