Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

Zhou, Lin, Liu, Chen, Sun, Zhengbo, Mao, Hongju, Zhang, Lin, Yu, Xuefeng, Zhao, Jianlong and Chen, Xianfeng (2019). Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis. Biosensors and Bioelectronics, 137 , pp. 140-147.


We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuron-specific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-L-lysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced light-matter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thickness-tunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cut-off value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

Publication DOI:
Divisions: Engineering & Applied Sciences > Electrical, Electronic & Power Engineering
Engineering & Applied Sciences > Aston Institute of Photonics Technology
Additional Information: © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: projects of EU FP7 PIRSES-GA-2013-612267 (iPhoto-Bio) and the Sêr Cymru NRN Fund (NRN097), and the National Natural Science Foundation of China (No.61571429 and 61801464).
Uncontrolled Keywords: Black phosphorus,Cancer biomarker,Fiber grating,Label-free,Neuron-specific enolase,Optical biosensor,Biotechnology,Biophysics,Biomedical Engineering,Electrochemistry
Full Text Link:
Related URLs: https://linking ... 956566319303343 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Online Date: 2019-07-15
Published Date: 2019-07-15
Authors: Zhou, Lin
Liu, Chen
Sun, Zhengbo
Mao, Hongju
Zhang, Lin ( 0000-0002-1691-5577)
Yu, Xuefeng
Zhao, Jianlong
Chen, Xianfeng



Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 25 April 2020.

License: Creative Commons Attribution Non-commercial No Derivatives

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