Biological and clinical insights from genetics of insomnia symptoms

Lane, Jacqueline M., Jones, Samuel E., Dashti, Hassan S., Wood, Andrew R., Aragam, Krishna G., van Hees, Vincent T., Strand, Linn B., Winsvold, Bendik S., Wang, Heming, Bowden, Jack, Song, Yanwei, Patel, Krunal, Anderson, Simon G., Beaumont, Robin N., Bechtold, David A., Cade, Brian E., Haas, Mary, Kathiresan, Sekar, Little, Max A., Luik, Annemarie I., Loudon, Andrew S., Purcell, Shaun, Richmond, Rebecca C., Scheer, Frank A.J.L., Schormair, Barbara, Tyrrell, Jessica, Winkelman, John W., Winkelmann, Juliane, Martinsen, Amy E., Skogholt, Anne H., Brumpton, Ben, Winsvold, Bendik S., Sivertsen, Børge, Willer, Cristen J., Bragantini, Daniela, Kallestad, Håvard, Janszky, Imre, Guzey, Ismail C., Zwart, John Anker, Nielsen, Jonas B., Nilsen, Kristian B., Hveem, Kristian, Fritsche, Lars, Pedersen, Linda M., Strand, Linn B., Gabrielsen, Maiken E., Johnsen, Marianne B., Lie, Marie U., Engstrøm, Morten and Sand, Trond (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics, 51 (3), 387–393.


Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.

Publication DOI:
Divisions: Engineering & Applied Sciences > Mathematics
Engineering & Applied Sciences > Systems analytics research institute (SARI)
Uncontrolled Keywords: Genetics
Full Text Link: https://ore.exe ... dle/10871/36068
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.nat ... 1588-019-0361-7 (Publisher URL)
http://sleepdis ... rmational/data/ (Related URL)
Published Date: 2019-02-25
Authors: Lane, Jacqueline M.
Jones, Samuel E.
Dashti, Hassan S.
Wood, Andrew R.
Aragam, Krishna G.
van Hees, Vincent T.
Strand, Linn B.
Winsvold, Bendik S.
Wang, Heming
Bowden, Jack
Song, Yanwei
Patel, Krunal
Anderson, Simon G.
Beaumont, Robin N.
Bechtold, David A.
Cade, Brian E.
Haas, Mary
Kathiresan, Sekar
Little, Max A. ( 0000-0002-1507-3822)
Luik, Annemarie I.
Loudon, Andrew S.
Purcell, Shaun
Richmond, Rebecca C.
Scheer, Frank A.J.L.
Schormair, Barbara
Tyrrell, Jessica
Winkelman, John W.
Winkelmann, Juliane
Martinsen, Amy E.
Skogholt, Anne H.
Brumpton, Ben
Winsvold, Bendik S.
Sivertsen, Børge
Willer, Cristen J.
Bragantini, Daniela
Kallestad, Håvard
Janszky, Imre
Guzey, Ismail C.
Zwart, John Anker
Nielsen, Jonas B.
Nilsen, Kristian B.
Hveem, Kristian
Fritsche, Lars
Pedersen, Linda M.
Strand, Linn B.
Gabrielsen, Maiken E.
Johnsen, Marianne B.
Lie, Marie U.
Engstrøm, Morten
Sand, Trond

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