Saffron (Crocus sativus L.) in ocular diseases:a narrative review of the existing evidence from clinical studies


Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.

Publication DOI:
Divisions: Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Optometry
Life & Health Sciences > Vision, Hearing and Language
Life & Health Sciences > Cell & Tissue Biomedical Research
Life & Health Sciences > Biosciences
Life & Health Sciences > Chronic and Communicable Conditions
Aston Medical School
Additional Information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Uncontrolled Keywords: AMD,Anti-inflammatory,Anti-oxidant,Crocetin,Crocin,Crocus Sativus L,Diabetes,Glaucoma,Saffron,Supplements,Food Science,Nutrition and Dietetics
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Related URLs: https://www.mdp ... 43/11/3/649/htm (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2019-03-18
Accepted Date: 2019-03-13
Authors: Heitmar, Rebekka ( 0000-0002-7657-1788)
Brown, James E ( 0000-0002-3504-7373)
Kyrou, Ioannis ( 0000-0002-6997-3439)



Version: Published Version

License: Creative Commons Attribution

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