Acute anterior uveitis, ankylosing spondylitis, back pain, and HLA-B27


One hundred and sixty-nine patients with acute anterior uveitis were studied for the presence of HLA-B27 tissue type, radiological evidence of ankylosing spondylitis, and a history of back pain. 60% were male; 45% were HLA-B27+. The male:female ratio in the HLA-B27+ group was the same as in the whole group. 24% had radiological evidence of ankylosing spondylitis, and, of these, 83% were HLA-B27+ while 17% were HLA-B27-. There was a definite correlation between the severity of the ankylosing spondylitis and preponderance of males in the HLA-B27+ group of patients. Significant back pain occurred in 60% of HLA-B27+ patients but in only 14% of HLA-B27- patients. The importance of the selection of patients and of consistency in the use of diagnostic criteria in studies relating to ankylosing spondylitis and acute anterior uveitis is stressed.

Divisions: Life & Health Sciences > Vision, Hearing and Language
Life & Health Sciences
Uncontrolled Keywords: Acute Disease,Back Pain,Female,HLA Antigens,HLA-B27 Antigen,Humans,Male,Sacroiliac Joint,Sex Factors,Spondylitis, Ankylosing,Uveitis, Anterior
Full Text Link: https://www.ncb ... les/PMC1040457/
Related URLs: http://bjo.bmj. ... ntent/68/10/741 (Publisher URL)
PURE Output Type: Article
Published Date: 1984-10
Authors: Beckingsale, Adrian B.
Davies, Jonathan
Gibson, Jonathan M. ( 0000-0002-9281-5244)
Rosenthal, A. Ralph

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