NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels

Zhang, Xuming, Huang, Jiehong and McNaughton, Peter A. (2005). NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO Journal, 24 (24), pp. 4211-4223.


Nociceptors, or pain-sensitive receptors, are unique among sensory receptors in that their sensitivity is increased by noxious stimulation. This process, called sensitization or hyperalgesia, is mediated by a variety of proinflammatory factors, including bradykinin, ATP and NGF, which cause sensitization to noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicin-gated ion channel, TRPV1. Several different mechanisms for sensitization of TRPV1 have been proposed. Here we show that NGF, acting on the TrkA receptor, activates a signalling pathway in which PI3 kinase plays a crucial early role, with Src kinase as the downstream element which binds to and phosphorylates TRPV1. Phosphorylation of TRPV1 at a single tyrosine residue, Y200, followed by insertion of TRPV1 channels into the surface membrane, explains most of the rapid sensitizing actions of NGF.

Publication DOI:
Divisions: Life & Health Sciences
Uncontrolled Keywords: Membrane trafficking,Neurotrophic factor,Pain,Sensory transduction,Tyrosine kinase,Genetics,Cell Biology
Full Text Link: https://www.ncb ... les/PMC1356334/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://emboj.em ... tent/24/24/4211 (Publisher URL)
Published Date: 2005-12-21
Authors: Zhang, Xuming ( 0000-0002-5331-8675)
Huang, Jiehong
McNaughton, Peter A.

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