Real-time label-free biosensing with integrated planar waveguide ring resonators

Sohlström, Hans, Gylfason, Kristinn B. and Hill, Daniel (2010). Real-time label-free biosensing with integrated planar waveguide ring resonators. Proceedings of SPIE - International Society for Optical Engineering, 7719 ,

Abstract

We review the use of planar integrated optical waveguide ring resonators for label free bio-sensing and present recent results from two European biosensor collaborations: SABIO and InTopSens. Planar waveguide ring resonators are attractive for label-free biosensing due to their small footprint, high Q-factors, and compatibility with on-chip optics and microfluidics. This enables integrated sensor arrays for compact labs-on-chip. One application of label-free sensor arrays is for point-of-care medical diagnostics. Bringing such powerful tools to the single medical practitioner is an important step towards personalized medicine, but requires addressing a number of issues: improving limit of detection, managing the influence of temperature, parallelization of the measurement for higher throughput and on-chip referencing, efficient light-coupling strategies to simplify alignment, and packaging of the optical chip and integration with microfluidics. From the SABIO project we report refractive index measurement and label-free biosensing in an 8-channel slotwaveguide ring resonator sensor array, within a compact cartridge with integrated microfluidics. The sensors show a volume sensing detection limit of 5 × 10-6 RIU and a surface sensing detection limit of 0.9 pg/mm2. From the InTopSens project we report early results on silicon-on-insulator racetrack resonators.

Publication DOI: https://doi.org/10.1117/12.855957
Divisions: Engineering & Applied Sciences > Institute of Photonics
Additional Information: Copyright 2010 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Uncontrolled Keywords: biosensing,lab-on-chip,label-free,light-coupling,microfluidics,packaging,ring resonators,slot waveguide,Electronic, Optical and Magnetic Materials,Condensed Matter Physics,Computer Science Applications,Applied Mathematics,Electrical and Electronic Engineering
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.spi ... /12.855957.full (Publisher URL)
Published Date: 2010-05-17
Authors: Sohlström, Hans
Gylfason, Kristinn B.
Hill, Daniel ( 0000-0003-3510-7783)

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