Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective

Nica, Dragos V., Draghici, George A., Andrica, Florina-maria, Popescu, Sofia, Coricovac, Dorina E., Dehelean, Cristina A., Gergen, Iosif I., Kovatsi, Leda, Coleman, Michael D. and Tsatsakis, Aristidis (2018). Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis: A gastropod perspective. Environmental Toxicology and Pharmacology ,


The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.

Publication DOI:
Divisions: Life & Health Sciences > Pharmacy
Life & Health Sciences
Additional Information: © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Uncontrolled Keywords: cadmium,copper,manganese,iron,dietary exposure,land snails
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Related URLs: https://linking ... 382668918305453 (Publisher URL)
Published Online Date: 2018-10-28
Authors: Nica, Dragos V.
Draghici, George A.
Andrica, Florina-maria
Popescu, Sofia
Coricovac, Dorina E.
Dehelean, Cristina A.
Gergen, Iosif I.
Kovatsi, Leda
Coleman, Michael D.
Tsatsakis, Aristidis



Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 28 October 2019.

License: Creative Commons Attribution Non-commercial No Derivatives

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