Aquaporins and Their Regulation after Spinal Cord Injury

Halsey, Andrea M, Conner, Alex C, Bill, Roslyn M, Logan, Ann and Ahmed, Zubair (2018). Aquaporins and Their Regulation after Spinal Cord Injury. Stem cells, 7 (10),

Abstract

After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord, AQP1, 4 and 9 contribute to spinal cord injury (SCI)-induced edema. AQP1, 4 and 9 are expressed in a variety of cells including astrocytes, neurons, ependymal cells, and endothelial cells. This review discusses some of the recent findings of the involvement of AQP in SCI and highlights the need for further study of these proteins to develop effective therapies to counteract the negative effects of SCI-induced edema.

Publication DOI: https://doi.org/10.3390/cells7100174
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Life & Health Sciences > Cellular and Molecular Biomedicine
Additional Information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Full Text Link:
Related URLs: http://www.mdpi ... 3-4409/7/10/174 (Publisher URL)
Published Date: 2018-10-18
Authors: Halsey, Andrea M
Conner, Alex C
Bill, Roslyn M ( 0000-0003-1331-0852)
Logan, Ann
Ahmed, Zubair

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