Cognitive impairment in children and adolescents with migraine

Termine, Cristiano, Bartoli, Beatrice, Agosti, Massimo A., Cavanna, Andrea E. and Balottin, Umberto (2018). Cognitive impairment in children and adolescents with migraine. Frontiers in Neurology, 9 ,

Abstract

INTRODUCTION The presence and characteristics of cognitive alterations in children and adolescents affected by migraine have been largely under-investigated. Childhood and adolescence are key periods for personal growth and academic achievements, and migraine-related cognitive deficits may interfere with functioning levels across several settings. A careful analysis of cognitive impairment in the context of migraine is pivotal for making informed decisions on the most appropriate care pathways. METHODS We therefore critically evaluated the results of research studies conducted to date on cognitive function in children and adolescents affected by migraine using the Pubmed database. The literature search was limited to original articles published in English language and focused on current research trends. We operationally defined cognitive processing as the range of individual cognitive functions assessed by neuropsychological studies. Our analysis, which did not include findings on cognitive processing assessed by neurophysiological measures for methodological consistency, led us to formulate the opinion that young patients affected by migraine may present with specific cognitive deficits. RESULTS An early neuropsychological study on young patients with migraine was conducted in 1989 on a group of 20 children affected by migraine without aura, aged between 7 and 11. The authors of this study did not identify clinically relevant impairment in cognitive performance, with the exception of impaired functioning in short and long-term memory tasks (1). A few years later, Haverkamp et al. (2) reported no significant differences between children with migraine aged 6–12 years and their healthy siblings on a measure of sequential and simultaneous information processing (2). Contrarily, Riva et al. (3) reported significant alterations in the information processing rate only. Patients with migraine showed delayed reaction times to visual stimuli compared to healthy controls; interestingly, reaction times were the only parameters showing a significant correlation with the pattern of headache episodes. The authors hypothesized the existence of reduced rates of information processing speed within the posterior cortical areas involved in detecting visual stimuli and within the premotor areas responsible for programming and implementing motor responses. The findings of this study were however limited by the absence of a matched control group (3).

Publication DOI: https://doi.org/10.3389/fneur.2018.00667
Divisions: Life & Health Sciences
Additional Information: Copyright © 2018 Termine, Bartoli, Agosti, Cavanna and Balottin. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords: Adolescent,Children,Cognitive aspect,Headache,Migraine,Neuropsychology,Neurology,Clinical Neurology
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.fro ... 2018.00667/full (Publisher URL)
Published Date: 2018-08-14
Authors: Termine, Cristiano
Bartoli, Beatrice
Agosti, Massimo A.
Cavanna, Andrea E.
Balottin, Umberto

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