Novel Polypeptides and Use Thereof

Abstract

A polypeptide capable of modulating tissue transglutaminase-induced cell behaviour comprises either (a) a heparin-binding site of a tissue transglutaminase (TG2), or a functional fragment, variant, fusion or derivative thereof, or an antibody capable of binding to the heparin-binding site of TG2, or a antigen-binding fragment or derivative thereof. Peptides comprising the heparin-binding site of TG2 bind to heparin-sulphate proteoglycans such as syndecan-4, and may be used for wound healing, and for use in medical implants. Antibodies binding to the heparin-binding site of TG2 may be useful for inhibiting angiogenesis, and treating fibrosis (including cystic fibrosis), scarring, neurodegenerative diseases, autoimmune diseases, thrombosis, cancer, AIDS, psoriasis, chronic inflammatory diseases, coeliac disease and organ transplant rejection.

Publication DOI: A61K38/04
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Cellular and Molecular Biomedicine
Aston University (General)
Full Text Link: http://worldwid ... 0655A&KC=A&ND=4
Related URLs:
PURE Output Type: Patent
Published Date: 2011-04-28
Authors: Collighan, Russell ( 0000-0003-0204-5125)
Griffin, Martin
Pytel, Kamila
Wang, Zhuo ( 0000-0002-2212-8318)

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