Dipeptide inhibitors of angiogenesis

Griffin, Martin (2011). Dipeptide inhibitors of angiogenesis. A61K38/05.


The present invention relates to inhibitors of tissue transglutaminase for use in the inhibition of angiogenesis in a subject. In particular, the invention provides compounds of Formula I for use in the treatment and/or prevention of angiogenic diseases and disorders of the eye, such as diabetic retinopathy and age-related macular degeneration (AMD). The invention further provides methods for inhibiting angiogenesis in a subject.

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