Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications

Isaacs, Mark A, Barbero, Brunella, Durndell, Lee J, Hilton, Anthony C, Olivi, Luca, Parlett, Christopher M A, Wilson, Karen and Lee, Adam F (2018). Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications. Antibiotics, 7 (3),


Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag₂CO₃ formation and the release of ionic silver in simulated tissue fluid. The Ag₂CO₃ concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA).

Publication DOI: https://doi.org/10.3390/antibiotics7030055
Divisions: Engineering & Applied Sciences
Life & Health Sciences > Cell & Tissue Biomedical Research
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences
Life & Health Sciences > Biosciences
Engineering & Applied Sciences > Chemical Engineering & Applied Chemistry
Engineering & Applied Sciences > European Bioenergy Research Institute (EBRI)
Additional Information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords: silver,antibacterial,titania,mesoporous,macroporous,surface functionalization
Full Text Link:
Related URLs: http://www.mdpi ... 079-6382/7/3/55 (Publisher URL)
Published Date: 2018-07-03
Authors: Isaacs, Mark A
Barbero, Brunella
Durndell, Lee J
Hilton, Anthony C ( 0000-0001-8025-5270)
Olivi, Luca
Parlett, Christopher M A ( 0000-0002-3651-7314)
Wilson, Karen ( 0000-0003-4873-708X)
Lee, Adam F



Version: Published Version

License: Creative Commons Attribution

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