Response of the Aging Eye to First Day of Modern Material Contact Lens Wear


Objectives:To investigate the ocular surface of an aged population wearing a daily disposable contact lens (CL) over their 1st day of wear.Methods:Forty eyes from 40 presbyopic subjects were fitted a daily CL (Delefilcon A). Tear osmolarity, tear meniscus area (TMA), and ocular surface aberrations (total higher-order root mean square [RMS]) were assessed at baseline (t 0 ), at 20 min (t 1 ) and after 8 hr (t 2 ) of wear. Fluorescein corneal and conjunctival staining and tear breakup time (TBUT) were performed at t 0 and t 2 .Results:No statistically significant changes were found between t 0 , t 1 , and t 2 for TMA and between t 0 and t 2 for fluorescein corneal and conjunctival staining. Tear breakup time worsened by the end of the day from 10.4±0.4 sec t 0 to 9.0±0.3 sec t 2 (P<0.05). Osmolarity showed significant changes between t 0 306.9±2.3 mOsm/L and t 1 312.4±2.4 mOsmol/L (P=0.02) but returned to baseline values at 8 hr (310.40±2.26 mOsm/L; P=0.09). Total higher-order RMS showed significant changes between t 0 0.38±0.02 m and t 1 0.61±0.04 m (P≤0.001) and between t 0 and t 2 0.64±0.41 m (P≤0.001).Conclusions:Delefilcon A may induce measures changes (osmolarity and TBUT values) in a presbyopic population; however, TMA and vital staining were maintained at the baseline level over the day.

Publication DOI:
Divisions: Life & Health Sciences > Optometry
Life & Health Sciences > Ophthalmic Research Group
Life & Health Sciences
Life & Health Sciences > Vision, Hearing and Language
Additional Information: This is the accepted version of the following article: Response of the Aging Eye to First Day of Modern Material Contact Lens Wear. Lafosse, Edouard, M.Sc.; Martínez-Albert, Noelia, M.Sc.; Wolffsohn, James S. W., Ph.D.; Cerviño, Alejandro, Ph.D.; García-Lázaro, Santiago, Ph.D. Eye & Contact Lens: June 25, 2018 - Volume Publish Ahead of Print - Issue - p doi: 10.1097/ICL.0000000000000514 Funding: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie SklodowskaCurie grant agreement No. 642760 EDEN ITN-EJD Project Horizon 2020 and “Atracció de Talent” research scholarship UV-INVPREDOC16F1-385061 (University of Valencia) awarded to Noelia Martínez.
Uncontrolled Keywords: Contact lenses,Multifocal,Osmolarity,Presbyopia,Ophthalmology
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PURE Output Type: Article
Published Date: 2019-01-01
Published Online Date: 2018-06-25
Accepted Date: 2018-03-13
Authors: Lafosse, Edouard
Martínez-albert, Noelia
Wolffsohn, James S. W. (ORCID Profile 0000-0003-4673-8927)
Cerviño, Alejandro
García-lázaro, Santiago



Version: Accepted Version

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