Reprint of: Proteomics in cardiovascular diseases::Unveiling sex and gender differences in the era of precision medicine

Baetta, Roberta, Pontremoli, Marta, Fernandez, Alma Martinez, Spickett, Corinne M and Banfi, Cristina (2018). Reprint of: Proteomics in cardiovascular diseases::Unveiling sex and gender differences in the era of precision medicine. Journal of Proteomics, 178 , pp. 57-72.

Abstract

Cardiovascular diseases (CVDs) represent the most important cause of mortality in women and in men. Contrary to the long-standing notion that the effects of the major risk factors on CVD outcomes are the same in both sexes, recent evidence recognizes new, potentially independent, sex/gender-related risk factors for CVDs, and sex/gender-differences in the clinical presentation of CVDs have been demonstrated. Furthermore, some therapeutic options may not be equally effective and safe in men and women. In this context, proteomics offers an extremely useful and versatile analytical platform for biomedical researches that expand from the screening of early diagnostic and prognostic biomarkers to the investigation of the molecular mechanisms underlying CDVs. In this review, we summarized the current applications of proteomics in the cardiovascular field, with emphasis on sex and gender-related differences in CVDs.

Publication DOI: https://doi.org/10.1016/j.jprot.2018.03.017
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Additional Information: © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords: Sex differences, Gender,Cardiovascular disease,Risk factors,Oxidative stress,Proteomics
Full Text Link:
Related URLs: https://www.sci ... 87439191830112X (Publisher URL)
Published Date: 2018-04-30
Authors: Baetta, Roberta
Pontremoli, Marta
Fernandez, Alma Martinez
Spickett, Corinne M ( 0000-0003-4054-9279)
Banfi, Cristina

Export / Share Citation


Statistics

Additional statistics for this record