Ca2+ regulation of TRP ion channels

Hasan, Raquibul and Zhang, Xuming (2018). Ca2+ regulation of TRP ion channels. International Journal of Molecular Sciences, 19 (4),


Ca2+ signaling influences nearly every aspect of cellular life. Transient receptor potential (TRP) ion channels have emerged as cellular sensors for thermal, chemical and mechanical stimuli and are major contributors to Ca2+ signaling, playing an important role in diverse physiological and pathological processes. Notably, TRP ion channels are also one of the major downstream targets of Ca2+ signaling initiated either from TRP channels themselves or from various other sources, such as G-protein coupled receptors, giving rise to feedback regulation. TRP channels therefore function like integrators of Ca2+ signaling. A growing body of research has demonstrated different modes of Ca2+-dependent regulation of TRP ion channels and the underlying mechanisms. However, the precise actions of Ca2+ in the modulation of TRP ion channels remain elusive. Advances in Ca2+ regulation of TRP channels are critical to our understanding of the diversified functions of TRP channels and complex Ca2+ signaling.

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Divisions: Life & Health Sciences
Additional Information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
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Related URLs: http://www.mdpi ... -0067/19/4/1256 (Publisher URL)
Published Date: 2018-04-23
Authors: Hasan, Raquibul
Zhang, Xuming ( 0000-0002-5331-8675)



Version: Published Version

License: Creative Commons Attribution

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