Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody

Hacohen, Yael, Messina, Silvia, Gan, Hoong-Wei, Wright, Sukhvir, Chandratre, Saleel, Leite, Maria Isabel, Fallon, Penny, Vincent, Angela, Ciccarelli, Olga, Wassmer, Evangeline, Lim, Ming, Palace, Jacqueline and Hemingway, Cheryl (2018). Endocrinopathies in paediatric-onset neuromyelitis optica spectrum disorder with aquaporin 4 (AQP4) antibody. Multiple Sclerosis Journal, 24 (5), pp. 679-684.


The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions. Morbid obesity was seen in 88% (7/8) of children of Caribbean origin. As endocrinopathies were prevalent in the majority of paediatric-onset AQP4-Ab NMOSD, endocrine surveillance and in particular early aggressive weight management is required for patients with AQP4-Ab NMOSD.

Publication DOI: https://doi.org/10.1177/1352458517726593
Divisions: Life & Health Sciences
Additional Information: © The Author(s), 2017. The final publication is available via Sage at http://dx.doi.org10.1177/1352458517726593
Uncontrolled Keywords: Journal Article
Full Text Link: http://discover ... /eprint/1561574
Related URLs: http://www.scop ... tnerID=MN8TOARS (Scopus URL)
https://journal ... 352458517726593 (Publisher URL)
Published Date: 2018-04-01
Authors: Hacohen, Yael
Messina, Silvia
Gan, Hoong-Wei
Wright, Sukhvir ( 0000-0002-5464-3779)
Chandratre, Saleel
Leite, Maria Isabel
Fallon, Penny
Vincent, Angela
Ciccarelli, Olga
Wassmer, Evangeline
Lim, Ming
Palace, Jacqueline
Hemingway, Cheryl



Version: Accepted Version

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