Manufacturing Exosomes:A Promising Therapeutic Platform


Extracellular vesicles, in particular the subclass exosomes, are rapidly emerging as a novel therapeutic platform. However, currently very few clinical validation studies and no clearly defined manufacturing process exist. As exosomes progress towards the clinic for treatment of a vast array of diseases, it is important to define the engineering basis for their manufacture early in the development cycle to ensure they can be produced cost-effectively at the appropriate scale. We hypothesize that transitioning to defined manufacturing platforms will increase consistency of the exosome product and improve their clinical advancement as a new therapeutic tool. We present manufacturing technologies and strategies that are being implemented and consider their application for the transition from bench-scale to clinical production of exosomes.

Publication DOI:
Divisions: Life & Health Sciences
Life & Health Sciences > Cell & Tissue Biomedical Research
Additional Information: © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: Ministry of Education, Science and Technology (grant No. 2009-0093829). Engineering and Physical Science Research Council (EPSRC) Industrial Doctoral Training Centre in Bioprocess Engineering Leadership (EP/G034656/1).
Uncontrolled Keywords: exosomes;,regenerative medicine,process development,commercial manufacturing
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Related URLs: http://linkingh ... 471491418300066 (Publisher URL)
PURE Output Type: Review article
Published Date: 2018-03
Published Online Date: 2018-02-12
Accepted Date: 2018-02-11
Authors: Colao, Ivano Luigi
Corteling, Randolph
Bracewell, Daniel
Wall, Ivan ( 0000-0001-6294-8348)

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