Photodynamic opening of blood-brain barrier

Abstract

Photodynamic treatment (PDT) causes a significant increase in the permeability of the blood-brain barrier (BBB) in healthy mice. Using different doses of laser radiation (635 nm, 10-40 J/cm2 ) and photosensitizer (5-aminolevulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we found that the optimal PDT for the reversible opening of the BBB is 15 J/cm2 and 5- ALA, 20 mg/kg, exhibiting brain tissues recovery 3 days after PDT. Further increases in the laser radiation or 5-ALA doses have no amplifying effect on the BBB permeability, but are associated with severe damage of brain tissues. These results can be an informative platform for further studies of new strategies in brain drug delivery and for better understanding of mechanisms underlying cerebrovascular effects of PDT-related fluorescence guided resection of brain tumor

Publication DOI: https://doi.org/10.1364/BOE.8.005040
Divisions: Engineering & Applied Sciences > Aston Institute of Photonics Technology
Uncontrolled Keywords: Medical optics and biotechnology, Medical and biological imaging,Blood or tissue constituent monitoring, Functional monitoring and imaging
Full Text Link:
Related URLs: https://www.osa ... i=boe-8-11-5040 (Publisher URL)
PURE Output Type: Article
Published Date: 2017-10-17
Published Online Date: 2017-10-17
Accepted Date: 2017-10-05
Authors: Semyachkina-glushkovskaya, Oxana
Kurths, Jürgen
Borisova, Ekaterina
Sokolovski, Sergei ( 0000-0001-7445-7204)
Mantareva, Vanya
Angelov, Ivan
Shirokov, Alexander
Navolokin, Nikita
Shushunova, Natalia
Khorovodov, Alexander
Ulanova, Maria
Sagatova, Madina
Agranivich, Ilana
Sindeeva, Olga
Gekalyuk, Artem
Bodrova, Anastasiya
Rafailov, Edik ( 0000-0002-4152-0120)

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