Type 2 diabetes in adolescents and young adults


The prevalence of type 2 diabetes in adolescents and young adults is dramatically increasing. Similar to older-onset type 2 diabetes, the major predisposing risk factors are obesity, family history, and sedentary lifestyle. Onset of diabetes at a younger age (defined here as up to age 40 years) is associated with longer disease exposure and increased risk for chronic complications. Young-onset type 2 diabetes also affects more individuals of working age, accentuating the adverse societal effects of the disease. Furthermore, evidence is accumulating that young-onset type 2 diabetes has a more aggressive disease phenotype, leading to premature development of complications, with adverse effects on quality of life and unfavourable effects on long-term outcomes, raising the possibility of a future public health catastrophe. In this Review, we describe the epidemiology and existing knowledge regarding pathophysiology, risk factors, complications, and management of type 2 diabetes in adolescents and young adults.

Publication DOI: https://doi.org/10.1016/S2213-8587(17)30186-9
Divisions: Life & Health Sciences > Biosciences
Life & Health Sciences
Life & Health Sciences > Chronic and Communicable Conditions
Life & Health Sciences > Cell & Tissue Biomedical Research
Life & Health Sciences > Psychology
Life & Health Sciences > Applied Health Research Group
Additional Information: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords: Internal Medicine,Endocrinology, Diabetes and Metabolism,Endocrinology
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-10-05
Published Online Date: 2017-08-15
Accepted Date: 2017-08-08
Authors: Lascar, Nadia ( 0000-0001-9997-366X)
Brown, James ( 0000-0002-3504-7373)
Pattison, Helen ( 0000-0002-9483-4342)
Barnett, Anthony H.
Bailey, Clifford J. ( 0000-0002-6998-6811)
Bellary, Srikanth ( 0000-0002-5924-5278)

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