Immune physiology in tissue regeneration and aging, tumor growth, and regenerative medicine

Bukovsky, Antonin, Caudle, Michael R., Carson, Ray J., Gaytán, Francisco, Huleihel, Mahmoud, Kruse, Andrea, Schatten, Heide and Telleria, Carlos M. (2009). Immune physiology in tissue regeneration and aging, tumor growth, and regenerative medicine. Aging, 1 (2), pp. 157-181.

Abstract

The immune system plays an important role in immunity (immune surveillance), but also in the regulation of tissue homeostasis (immune physiology). Lessons from the female reproductive tract indicate that immune system related cells, such as intraepithelial T cells and monocyte-derived cells (MDC) in stratified epithelium, interact amongst themselves and degenerate whereas epithelial cells proliferate and differentiate. In adult ovaries, MDC and T cells are present during oocyte renewal from ovarian stem cells. Activated MDC are also associated with follicular development and atresia, and corpus luteum differentiation. Corpus luteum demise resembles rejection of a graft since it is attended by a massive influx of MDC and T cells resulting in parenchymal and vascular regression. Vascular pericytes play important roles in immune physiology, and their activities (including secretion of the Thy-1 differentiation protein) can be regulated by vascular autonomic innervation. In tumors, MDC regulate proliferation of neoplastic cells and angiogenesis. Tumor infiltrating T cells die among malignant cells. Alterations of immune physiology can result in pathology, such as autoimmune, metabolic, and degenerative diseases, but also in infertility and intrauterine growth retardation, fetal morbidity and mortality. Animal experiments indicate that modification of tissue differentiation (retardation or acceleration) during immune adaptation can cause malfunction (persistent immaturity or premature aging) of such tissue during adulthood. Thus successful stem cell therapy will depend on immune physiology in targeted tissues. From this point of view, regenerative medicine is more likely to be successful in acute rather than chronic tissue disorders.

Publication DOI: https://doi.org/10.18632/aging.100024
Divisions: Aston Medical School
Additional Information: © 2009 Bukovsky et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Uncontrolled Keywords: Geriatrics and Gerontology
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2009-02-13
Authors: Bukovsky, Antonin
Caudle, Michael R.
Carson, Ray J. ( 0000-0002-9192-1782)
Gaytán, Francisco
Huleihel, Mahmoud
Kruse, Andrea
Schatten, Heide
Telleria, Carlos M.

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