B1 cells promote pancreas infiltration by autoreactive T cells

Ryan, Gemma A, Wang, Chun Jing, Chamberlain, Jayne L., Attridge, Kesley, Schmidt, Emily M., Kenefeck, Rupert, Clough, Louise E., Dunussi-Joannopoulos, Kyri, Toellner, Kai-Michael and Walker, Lucy S.K. (2010). B1 cells promote pancreas infiltration by autoreactive T cells. Journal of Immunology, 185 (5), pp. 2800-2807.


The entry of autoreactive T cells into the pancreas is a critical checkpoint in the development of autoimmune diabetes. In this study, we identify a role for B1 cells in this process using the DO11 x RIP-mOVA mouse model. In transgenic mice with islet-specific T cells, but no B cells, T cells are primed in the pancreatic lymph node but fail to enter the pancreas. Reconstitution of the B1 cell population by adoptive transfer permits extensive T cell pancreas infiltration. Reconstituted B1 cells traffic to the pancreas and modify expression of adhesion molecules on pancreatic vasculature, notably VCAM-1. Despite substantial pancreas infiltration, islet destruction is minimal unless regulatory T cells are depleted. These data identify a role for B1 cells in permitting circulating islet-specific T cells to access their Ag-bearing tissue and emphasize the existence of multiple checkpoints to regulate autoimmune disease.

Publication DOI: https://doi.org/10.4049/jimmunol.1000856
Divisions: Life & Health Sciences
Life & Health Sciences > Cell & Tissue Biomedical Research
Uncontrolled Keywords: adoptive transfer,autoimmune diseases,B-lymphocyte subsets,CD8-positive T-lymphocytes,cell movement,diabetes mellitus,islets of Langerhans,lymphocyte depletion,ovalbumin,vascular cell adhesion molecule-1
Full Text Link: https://www.ncb ... les/PMC3983558/
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Published Date: 2010-09-01
Authors: Ryan, Gemma A
Wang, Chun Jing
Chamberlain, Jayne L.
Attridge, Kesley ( 0000-0003-4521-9009)
Schmidt, Emily M.
Kenefeck, Rupert
Clough, Louise E.
Dunussi-Joannopoulos, Kyri
Toellner, Kai-Michael
Walker, Lucy S.K.

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